How much weight drop is safe?

I have a serious question, in the past I have safely dropped about 15 lbs., now I have a weigh in on Fri, and I must drop to 205, this morning I weighed in at 225 lbs. I was wondering if anyone could tell me if this would be safe, also I am currently taking, some NO-2, No-Explode, and Cell Mass (which is creatine). Can I pull the water without hurting myself. I assumed that I am holding alot of water with the Creatine and all. Any help A.S.A.P will be appriciated.

Thanks, Wild Apache