Webpage admin problem

The database (Mambo) for a webpage that I maintain will not save at all on my home computer, but will at my work computer. I click 'save' to keep changes and nothing happens.

A friend suggested it was spyware. I ran Adaware and Spybot several times. Spybot kept coming up that 'DSO Exploit' would not delete 2 of 3 items.

So:

-Does anyone have ideas on what the problem is?

or

-What remover do I need for the spyware?

thanks