Setting up the overhand right?

How would you go about setting up the overhand right, both defensively and offensively, for both amateur boxing and MMA?

Infighting....If the opponent tries to pull away, it's a PERFECT time to throw it.

Thanks Toki!

How about dipping under a jab and throwing the overhand right?

if you are the type of person that steps with their jab, then you can immediately throw the overhand after the jab. I know that's kind of obvious